For decades, N-methyl-D-aspartate (NMDA) receptors have been known to play a critical
role in the modulation of both acute and chronic pain. Of particular interest are NMDA …

Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of
synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to …

The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …

Pain is a sensory state resulting from complex integration of peripheral nociceptive inputs
and central processing. Pain consists of adaptive pain that is acute and beneficial for …

Abstract Fragile X Mental Retardation Protein (FMRP) regulates activity‐dependent RNA
localization and local translation to modulate synaptic plasticity throughout the central …

The GluN2 subunits of N-methyl-d-aspartate receptors (NMDARs) are key drivers of synaptic
plasticity in the brain, where the particular GluN2 composition endows the NMDAR complex …

Many cases of accidental death associated with drug overdose are due to chronic opioid
use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased …

One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …

The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of
nociceptive messages. Plastic changes in the properties of neuronal networks in the DH …

Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and
ketamine cause psychosis‐like symptoms in healthy humans, exacerbate schizophrenia …