The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …

Topoisomerases are ubiquitous enzymes involved in maintaining genomic stability of the
cell by regulating the over-or underwinding of DNA strands. Besides their customary …

Two major mechanisms have been causally implicated in the establishment of cellular
senescence: the activation of the DNA damage response (DDR) pathway and the formation …

The eukaryotic genome can be roughly divided into euchromatin and heterochromatin
domains that are structurally and functionally distinct. Heterochromatin is characterized by its …

Annually, ovarian cancer (OC) affects 240,000 women worldwide and is the most lethal
gynecological malignancy. High‐grade serous OC (HGSOC) is the most common and …

Senescence is an irreversible cell‐cycle arrest that is elicited by a wide range of factors,
including replicative exhaustion. Emerging evidences suggest that cellular senescence …

Cellular homeostasis declines with age due to the declining fidelity of biosynthetic
processes and the accumulation of molecular damage. Yet, it remains largely elusive how …

Cellular senescence is a state of stable and irreversible cell cycle arrest with active
metabolism, that normal cells undergo after a finite number of divisions (Hayflick limit) …

Understanding the molecular mechanisms and biological consequences of genetic changes
occurring during bypass of cellular senescence spans a broad area of medical research …

Background Human lifespan is approximately 25% heritable, and genetic factors may be
particularly important for achieving exceptional longevity. Accordingly, siblings of …