Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

Mitragynine, an alkaloid found in Mitragyna speciosa (kratom), shows promise as a potential
alternative to opioids owing to its distinctive indole alkaloid structure and its capacity for pain …

Discovering natural product biosynthetic pathways of medicinal plants is challenging and
laborious. Capturing the coregulation patterns of pathway enzymes, particularly …

Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that
include a number of medicinally important compounds. We set out to reconstitute the …

Natural products have made a crucial and unique contribution to human health, and this is
especially true in the case of malaria, where the natural products quinine and artemisinin …

a methoxy group that has been assumed to be incorporated at a late pathway stage. Here
we show that the methoxy group in quinine and related alkaloids is introduced onto the …

Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer
alternative to clinical opioids such as morphine, owing to its more favorable side effect …

Mitragyna speciosa (“kratom”) is used as a natural remedy for pain and management of
opioid dependence. The pharmacological properties of kratom have been linked to a …

The antiarrhythmic drug ajmaline is a monoterpenoid indole alkaloid (MIA) isolated from the
Ayurvedic plant Rauvolfia serpentina (Indian Snakeroot). Research into the biosynthesis of …