To apply genomic knowledge effectively in drug discovery, mechanistic connectivities
between genetic variation and disease processes need to be established via systems …

The metabolic conjugation of exogenous and endogenous carboxylic acid substrates with
endogenous glucuronic acid, mediated by the uridine diphosphoglucuronosyl transferase …

The Sir2 (silentinformation regulator 2) family of histone/protein deacetylases has been
implicated in a wide range of biological activities, including gene silencing, life-span …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Nuclear magnetic resonance spectroscopy (NMR) is arguably the most versatile analytical
platform for complex mixture analysis. Specifically, interfacing liquid chromatography with …

Background: Carboxylic acids constitute a large and heterogeneous class of both
endogenous and xenobiotic compounds. A number of carboxylic acid drugs have been …

Cryogenic cooling of the NMR radio frequency coils and electronics to give greatly
enhanced sensitivity is arguably the most significant recent advance in NMR spectroscopy …

In a definitive review of 1987, Kaspersen and van Boeckel1 presented a concise account of
the chemical synthesis of glucuronide and sulfate conjugates of xenobiotics. At that time, O …

The rates at which biological interactions occur can provide important information
concerning the mechanism and behavior of these processes in living systems. This review …

This review continues a general presentation of the metabolism of drugs and other
xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is …