Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives

F Wen, G Gui, X Wang, L Ye, A Qin, C Zhou… - Bioorganic & Medicinal …, 2024 - Elsevier
Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD+) salvage pathway, primarily catalyzing the …

Myricanol prevents aging‐related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5

S Shen, Q Liao, P Lyu, J Wang, L Lin - MedComm, 2024 - Wiley Online Library
Aging is a process that represents the accumulation of changes in organism overtime. In
biological level, accumulations of molecular and cellular damage in aging lead to an …

Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated …

K Liu, L Yang, P Wang, J Zhu, F Li, J Peng… - …, 2024 - Springer
Sepsis, a life-threatening condition characterized by dysregulated immune responses,
remains a significant clinical challenge. Myricanol, a natural compound, plays a variety of …

Unveiling the secrets using bioorthogonal chemistry to explore the impact of adipokines on male reproduction and infertility

S Dutta, P Sengupta - Journal of Molecular Chemistry, 2024 - pubs.thesciencein.org
Adipocytes secrete bioactive peptides known as adipokines, which have diverse
physiological functions related to metabolic homeostasis, inflammation, and energy …