The approval of the first immune checkpoint inhibitors provided a paradigm shift for the
treatment of malignancies across a broad range of indications. Whereas initially, single …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor
microenvironment (TME). They link innate to adaptive immunity by processing and …

Efficacy of cancer vaccines remains low and mechanistic understanding of antigen
presenting cell function in cancer may improve vaccine design and outcomes. Here, we …

Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

Mycobacterium tuberculosis (Mtb)-infected neutrophils are often found in the airways of
patients with active tuberculosis (TB), and excessive recruitment of neutrophils to the lung is …

Abstract α-Fetoprotein (AFP) is expressed by stem-like and poor outcome hepatocellular
cancer tumors and is a clinical tumor biomarker. AFP has been demonstrated to inhibit …

Mounting evidence progressively appreciates the vital interplay between immunity and
metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and …

The old age‐related loss of immune tolerance inflicts a person with a wide range of
autoimmune and inflammatory diseases. Dendritic cells (DCs) are the sentinels of the …

Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive
studies have demonstrated that metabolic decisions influence immune cell activation …