A full understanding of protein structure is key to unraveling how these systems work, how
mutations affect their function, and discovering new hotspots for drug discovery. Research …

Respiratory viral infections are a major public health problem, with much of their morbidity
and mortality due to post-viral lung diseases that progress and persist after the active …

Protein kinase function and interactions with drugs are controlled in part by the movement of
the DFG and ɑC-Helix motifs that are related to the catalytic activity of the kinase. Small …

Reversible protein phosphorylation directs essential cellular processes including cell
division, cell growth, cell death, inflammation, and differentiation. Because protein …

Computational approaches can provide highly detailed insight into the molecular
recognition processes that underlie drug binding, the assembly of protein complexes, and …

Resistance in pathogenic fungi necessitates the development of fungicides with new
mechanisms of action. The Mps1 MAPK of Magnaporthe oryzae, the pathogen of rice blast …

In order to survive and fulfil their functions, cells of any organism need to be able to respond
to a large number of extracellular factors, also termed extracellular stimuli. These responses …

Low back pain due to epidural fibrosis is a major complication after spine surgery.
Macrophages infiltrate the wound area post laminectomy, but the role of macrophages in …

The dual-specificity protein kinase MKK3 has been implicated in tumor cell proliferation and
survival, yet its precise role in cancer remains inconclusive. A critical step in elucidating the …

The stress kinase MAPK13 (aka p38δ-MAPK) is an attractive entry point for therapeutic
intervention because it regulates the structural remodeling that can develop after epithelial …