Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …

Small GTPases of the rab family are crucial elements of the machinery that controls
membrane traffic. In the present study, we examined the distribution and function of rab11 …

Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

Receptor recycling involves two endosome populations, peripheral early endosomes and
perinuclear recycling endosomes. In polarized epithelial cells, either or both populations …

We have identified a novel 100 kDa coiled-coil protein, rabaptin-5, that specifically interacts
with the GTP form of the small GTPase Flab& a potent regulator of endocytic transport. It is …

Primary cilia are sensory structures involved in morphogen signalling during development,
liquid flow in the kidney, mechanosensation, sight, and smell (Badano, JL, N. Mitsuma, PL …