The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …

Stabilization and activation of the p53 tumor suppressor are triggered in response to various
cellular stresses, including DNA damaging agents and elevated Reactive Oxygen Species …

Abstract Reactive Oxygen Species (ROS) derived from mitochondrial respiration are
frequently cited as a major source of chromosomal DNA mutations that contribute to cancer …

Copper (Cu), as a common chemical contaminant in environment, is known to be toxic at
high concentrations. The current research demonstrates the effects of copper upon …

Cancer cells often experience high basal levels of DNA replication stress (RS), for example
due to hyperactivation of oncoproteins like MYC or RAS. Therefore, cancer cells are …

Abstract Reactive Oxygen Species (ROS) derived from mitochondrial respiration are
frequently cited as a major source of genomic DNA damage and subsequent mutations that …

Fbxo5 (F-Box only protein 5), as a substrate recognition subunit of SCF (SKP1-Cullin1-Fbox)
protein, plays a crucial role in various cellular processes through ubiquitination and …

The revolution in aging research through the past decade has driven the progress in
interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided …

Replication stress risks genomic integrity. Depending on the level, replication stress can
lead to slower progression through S phase and entry into G2 phase with DNA damage. In …