Ultrasound produces extensive brain activation via a cochlear pathway

H Guo, M Hamilton, SJ Offutt, CD Gloeckner, T Li… - Neuron, 2018 - cell.com
Ultrasound (US) can noninvasively activate intact brain circuits, making it a promising
neuromodulation technique. However, little is known about the underlying mechanism …

Auditory midbrain implant: a review

HH Lim, M Lenarz, T Lenarz - Trends in amplification, 2009 - journals.sagepub.com
The auditory midbrain implant (AMI) is a new hearing prosthesis designed for stimulation of
the inferior colliculus in deaf patients who cannot sufficiently benefit from cochlear implants …

Auditory midbrain implant: research and development towards a second clinical trial

HH Lim, T Lenarz - Hearing research, 2015 - Elsevier
The cochlear implant is considered one of the most successful neural prostheses to date,
which was made possible by visionaries who continued to develop the cochlear implant …

A discontinuous tonotopic organization in the inferior colliculus of the rat

MS Malmierca, MA Izquierdo, S Cristaudo… - Journal of …, 2008 - Soc Neuroscience
Audible frequencies of sound are encoded in a continuous manner along the length of the
cochlea, and frequency is transmitted to the brain as a representation of place on the basilar …

Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment

TG Landry, AK Wise, JB Fallon, RK Shepherd - Hearing research, 2011 - Elsevier
Cochlear implants electrically stimulate residual spiral ganglion neurons (SGNs) to provide
auditory cues for the severe-profoundly deaf. However, SGNs gradually degenerate …

The generation of direction selectivity in the auditory system

RI Kuo, GK Wu - Neuron, 2012 - cell.com
Both human speech and animal vocal signals contain frequency-modulated (FM) sounds.
Although central auditory neurons that selectively respond to the direction of frequency …

Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system

HH Lim, T Lenarz, G Joseph, RD Battmer… - Journal of …, 2007 - Soc Neuroscience
The cochlear implant can restore speech perception in patients with sensorineural hearing
loss. However, it is ineffective for those without an implantable cochlea or a functional …

Differential distribution of GABA and glycine terminals in the inferior colliculus of rat and mouse

D Choy Buentello, DC Bishop… - Journal of Comparative …, 2015 - Wiley Online Library
The inferior colliculus (IC), the midbrain component of the auditory pathway, integrates
virtually all inputs from the auditory brainstem. These are a mixture of excitatory and …

Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear …

TG Landry, JB Fallon, AK Wise… - Journal of Comparative …, 2013 - Wiley Online Library
Cochlear implants restore hearing cues in the severe–profoundly deaf by electrically
stimulating spiral ganglion neurons (SGNs). However, SGNs degenerate following loss of …

Tonotopic organization in the depth of human inferior colliculus

D Ress, B Chandrasekaran - Frontiers in human neuroscience, 2013 - frontiersin.org
Experiments in animal models indicate that inferior colliculus (IC), the primary auditory
midbrain structure, represents sound frequency in a particular spatial organization, a …