PrP genetics in ruminant transmissible spongiform encephalopathies

W Goldmann - Veterinary research, 2008 - hal.science
Scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) are
prion diseases in ruminants with considerable impact on animal health and welfare. They …

Update on classical and atypical scrapie in sheep and goats

JJ Greenlee - Veterinary pathology, 2019 - journals.sagepub.com
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

[HTML][HTML] State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology

G Vaccari, CH Panagiotidis, C Acin, S Peletto… - Veterinary …, 2009 - ncbi.nlm.nih.gov
Scrapie is a fatal, neurodegenerative disease of sheep and goats. It is also the earliest
known member in the family of diseases classified as transmissible spongiform …

Classical and atypical scrapie in sheep and goats. Review on the etiology, genetic factors, pathogenesis, diagnosis, and control measures of both diseases

C Acín, R Bolea, M Monzón, E Monleón, B Moreno… - Animals, 2021 - mdpi.com
Simple Summary Classical scrapie is a prionic, neurological, consumptive, and chronic
disease that affects naturally domestic small ruminants. It was initially described in the UK …

Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep

JPM Langeveld, JG Jacobs, JHF Erkens… - BMC veterinary …, 2006 - Springer
Background Diagnosis based on prion detection in lymph nodes of sheep and goats can
improve active surveillance for scrapie and, if it were circulating, for bovine spongiform …

Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with …

F Barillet, D Mariat, Y Amigues… - Journal of General …, 2009 - microbiologyresearch.org
In sheep, susceptibility to scrapie is mainly influenced by polymorphisms of the PrP gene. In
goats, there are to date few data related to scrapie susceptibility association with PrP gene …

The transmissible spongiform encephalopathies of livestock

JJ Greenlee, MHW Greenlee - ILAR journal, 2015 - academic.oup.com
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal protein-
misfolding neurodegenerative diseases. TSEs have been described in several species …

Genetic resistance to scrapie infection in experimentally challenged goats

C Lacroux, C Perrin-Chauvineau, F Corbière… - Journal of …, 2014 - Am Soc Microbiol
In goats, several field studies have identified coding mutations of the gene encoding the
prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a …

Prion and prion-like diseases in animals

P Aguilar-Calvo, C García, JC Espinosa, O Andreoletti… - Virus research, 2015 - Elsevier
Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases
characterized by the aggregation and accumulation of the misfolded prion protein in the …

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene

PL Acutis, F Martucci, A D'Angelo, S Peletto… - Veterinary …, 2012 - Springer
Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small
ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP) …