Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …

Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …

Purpose: A first-in-human pilot safety and feasibility trial evaluating chimeric antigen
receptor (CAR)–engineered, autologous primary human CD8+ cytotoxic T lymphocytes …

Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …

Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …

Background The macrophage, one of the several key immune cell types, is believed to be
involved in tumorigenesis. However, the mechanism of macrophages promoting tumor …

Abstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate …

Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma.
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in …