It has long been reported that Mycobacterium tuberculosis is capable of synthesizing the α-
glucan glycogen. However, what makes this bacterium stand out is that it coats itself in a …

Computer-aided drug discovery and development approaches such as virtual screening,
molecular docking, and in silico drug property calculations have been utilized in this effort to …

Aims: The present study aimed to search for novel potent inhibitor (s) against the recently
discovered maltosyltransferase (GlgE) target of M. tb. Background: GlgE belongs to an α …

Introduction Cancer is considered as one of the deadliest human diseases today.
Angiogenesis, the propagation of new blood vessels from pre-existing vasculature, is a …

The rise of superbugs is a serious public health concern. It is estimated to kill around 10
million people a year by 2050 and will overtake cancer as the number one cause of death …

GlgE is a maltosyltransferase involved in α-glucan biosynthesis in bacteria that has been
genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium …

The viral infection caused by the dengue virus (DENV) is one of the most challenging
diseases in the tropical regions of the world. The absence of drugs for dengue to this date …

Retusenol is a new triterpene discovered from the leaf extracts of Atalantia retusa Merr., a
Philippine endemic shrub. With the emergence of drug resistance and drug tolerance in …

Tuberculosis (TB) is the leading cause of death globally as a result of a single infectious
disease. A staggering 6 million new cases were reported in the 2014. In order to eradicate …

GlgE is a maltosyltransferase involved in αglucan biosynthesis in bacteria that has been
genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium …