SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic
levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome …

Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within
its ring-shaped structure. It was originally identified and named for its role in mediating sister …

The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct
protein isoforms, which are expressed in a combinatorial manner to generate enormous …

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin
complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …