Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
C Tay, A Tanaka, S Sakaguchi - Cancer Cell, 2023 - cell.com
Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
Y Kidani, W Nogami, Y Yasumizu… - Proceedings of the …, 2022 - National Acad Sciences
Foxp3-expressing CD25+ CD4+ regulatory T cells (Tregs) are abundant in tumor tissues.
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
Here, hypothesizing that tumor Tregs would clonally expand after they are activated by …
Regulatory T cells in cancer immunotherapy
A Tanaka, S Sakaguchi - Cell research, 2017 - nature.com
FOXP3-expressing regulatory T (Treg) cells, which suppress aberrant immune response
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
CD4 T-cell subsets and the pathophysiology of inflammatory bowel disease
R Gomez-Bris, A Saez, B Herrero-Fernandez… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
VA Gerriets, RJ Kishton, MO Johnson, S Cohen… - Nature …, 2016 - nature.com
CD4+ effector T cells (Teff cells) and regulatory T cells (Treg cells) undergo metabolic
reprogramming to support proliferation and immunological function. Although signaling via …
reprogramming to support proliferation and immunological function. Although signaling via …
Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
BH Yang, S Hagemann, P Mamareli, U Lauer… - Mucosal …, 2016 - nature.com
Foxp3 (forkhead box P3 transcription factor)-expressing regulatory T cells (Tregs) are
essential for immunological tolerance, best illustrated by uncontrolled effector T-cell …
essential for immunological tolerance, best illustrated by uncontrolled effector T-cell …
Continuous requirement for the TCR in regulatory T cell function
Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance, and their deficiency
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …