Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
[HTML][HTML] Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …
EGF receptor trafficking: consequences for signaling and cancer
A Tomas, CE Futter, ER Eden - Trends in cell biology, 2014 - cell.com
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
[HTML][HTML] Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
Y Du, H Yamaguchi, Y Wei, JL Hsu, HL Wang… - Nature medicine, 2016 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
[HTML][HTML] The nuclear epidermal growth factor receptor signaling network and its role in cancer
TM Brand, M Iida, C Li, DL Wheeler - Discovery medicine, 2011 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …
The paradoxical functions of EGFR during breast cancer progression
R Ali, MK Wendt - Signal transduction and targeted therapy, 2017 - nature.com
The epidermal growth factor receptor (EGFR) is one of the most well-studied signaling
pathways in cancer progression. As a result, numerous therapeutics including small …
pathways in cancer progression. As a result, numerous therapeutics including small …