Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …

Background Patients with myeloma who relapse after high-dose chemotherapy have few
therapeutic options. Since increased bone marrow vascularity imparts a poor prognosis in …

The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

Human multiple myeloma (MM) is a presently incurable hematological malignancy, and
novel biologically based therapies are urgently needed. Proteasome inhibitors represent a …

The proteasome is an abundant multi-enzyme complex that provides the main pathway for
degradation of intracellular proteins in eukaryotic cells. As such, it controls the levels of …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …

Multiple myeloma is a plasma cell malignancy characterized by complex heterogeneous
cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma …

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which
chromosome translocations frequently place oncogenes under the control of …

The process of angiogenesis encompasses the growth and regression of capillary blood
vessels. Angiogenesis is finely regulated at the molecular and genetic levels, not unlike …