Abstract Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …

HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

Given its predominant expression in the central nervous system (CNS), 5-hydroxytryptamine
(5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for …

Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most
circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in …

Abstract The serotonin (5-HT) 6 receptor is a Gs-coupled receptor exclusively expressed in
the central nervous system. Highest receptor densities are found in brain regions implicated …

5-hydroxytryptamine6 receptor (5-HT6R) antagonists have shown efficacy in animal models
for cognitive impairment in multiple cognitive domains relevant for schizophrenia …

Chronic neuropathic pain is a highly disabling syndrome that is poorly controlled by
currently available analgesics. Here, we show that painful symptoms and associated …

The role of 5-HT receptors in fluoxetine-induced nociception and antinociception in rats was
assessed. Formalin produced a typical pattern of flinching and licking/lifting behaviors. Local …