Multiple roles of serotonin in pain control mechanisms—implications of 5-HT7 and other 5-HT receptor types
F Viguier, B Michot, M Hamon, S Bourgoin - European journal of …, 2013 - Elsevier
Abstract Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
QQ Liu, XX Yao, SH Gao, R Li, BJ Li, W Yang… - Pharmacological …, 2020 - Elsevier
HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …
The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system
ZY Tao, PX Wang, SQ Wei, RJ Traub, JF Li… - Neural …, 2019 - Wiley Online Library
Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
Role of descending serotonergic fibers in the development of pathophysiology after spinal cord injury (SCI): Contribution to chronic pain, spasticity, and autonomic …
GNK Fauss, KE Hudson, JW Grau - Biology, 2022 - mdpi.com
Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
Therapeutic Potential of 5-HT6 Receptor Agonists: Miniperspective
D Karila, T Freret, V Bouet, M Boulouard… - Journal of medicinal …, 2015 - ACS Publications
Given its predominant expression in the central nervous system (CNS), 5-hydroxytryptamine
(5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for …
(5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for …
The serotonergic system dysfunction in diabetes mellitus
Y Cai, X Li, H Zhou, J Zhou - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most
circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in …
circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in …
The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
Abstract The serotonin (5-HT) 6 receptor is a Gs-coupled receptor exclusively expressed in
the central nervous system. Highest receptor densities are found in brain regions implicated …
the central nervous system. Highest receptor densities are found in brain regions implicated …
5-HT6 receptor antagonists: potential efficacy for the treatment of cognitive impairment in schizophrenia
N MWJ de Bruin, CG Kruse - Current Pharmaceutical Design, 2015 - ingentaconnect.com
5-hydroxytryptamine6 receptor (5-HT6R) antagonists have shown efficacy in animal models
for cognitive impairment in multiple cognitive domains relevant for schizophrenia …
for cognitive impairment in multiple cognitive domains relevant for schizophrenia …
[HTML][HTML] mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment
PY Martin, S Doly, E Chapuy, V Canale, M Drop… - Progress in …, 2020 - Elsevier
Chronic neuropathic pain is a highly disabling syndrome that is poorly controlled by
currently available analgesics. Here, we show that painful symptoms and associated …
currently available analgesics. Here, we show that painful symptoms and associated …
Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats
C Cervantes-Durán, HI Rocha-Gonzalez… - Neuroscience, 2013 - Elsevier
The role of 5-HT receptors in fluoxetine-induced nociception and antinociception in rats was
assessed. Formalin produced a typical pattern of flinching and licking/lifting behaviors. Local …
assessed. Formalin produced a typical pattern of flinching and licking/lifting behaviors. Local …