Molecular crosstalk between cancer and neurodegenerative diseases

J Seo, M Park - Cellular and Molecular Life Sciences, 2020 - Springer
The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Advances in the characterization of RNA‐binding proteins

D Marchese, NS de Groot… - Wiley …, 2016 - Wiley Online Library
From transcription, to transport, storage, and translation, RNA depends on association with
different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and …

RNA structure drives interaction with proteins

N Sanchez de Groot, A Armaos… - Nature …, 2019 - nature.com
The combination of high-throughput sequencing and in vivo crosslinking approaches leads
to the progressive uncovering of the complex interdependence between cellular …

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

P Aramillo Irizar, S Schäuble, D Esser, M Groth… - Nature …, 2018 - nature.com
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic
disorders as dominant contributors to mortality in the old. Nevertheless, it has remained …

Examples of inverse comorbidity between cancer and neurodegenerative diseases: a possible role for noncoding RNA

M Salemi, MP Mogavero, G Lanza, LM Mongioì… - Cells, 2022 - mdpi.com
Cancer is one of the most common causes of death; in parallel, the incidence and
prevalence of central nervous system diseases are equally high. Among neurodegenerative …

Loss of microglial EED impairs synapse density, learning, and memory

YY Wang, YS Deng, SK Dai, TW Mi, RY Li, PP Liu… - Molecular …, 2022 - nature.com
The embryonic ectoderm development (EED) is a core component of the polycomb-
repressive complex 2 (PRC2) whose mutations are linked to neurodevelopmental …

Tau affects P53 function and cell fate during the DNA damage response

M Sola, C Magrin, G Pedrioli, S Pinton… - Communications …, 2020 - nature.com
Cells are constantly exposed to DNA damaging insults. To protect the organism, cells
developed a complex molecular response coordinated by P53, the master regulator of DNA …

Emerging evidences for an implication of the neurodegeneration-associated protein tau in cancer

S Papin, P Paganetti - Brain sciences, 2020 - mdpi.com
Neurodegenerative disorders and cancer may appear unrelated illnesses. Yet,
epidemiologic studies indicate an inverse correlation between their respective incidences …

Parkinson's disease and cancer: a systematic review and meta-analysis of over 17 million participants

X Zhang, D Guarin, N Mohammadzadehhonarvar… - BMJ open, 2021 - bmjopen.bmj.com
Objective To systematically review and qualitatively evaluate epidemiological evidence on
associations between Parkinson's disease (PD) and cancer via meta-analysis. Data sources …

Focus on the complex interconnection between cancer, narcolepsy and other neurodegenerative diseases: a possible case of orexin-dependent inverse comorbidity

MP Mogavero, A Silvani, LM DelRosso, M Salemi… - Cancers, 2021 - mdpi.com
Simple Summary This narrative review first describes from several points of view the
complex interrelationship between cancer and neurodegeneration, with special attention to …