Area-Under-Curve–Guided Versus Trough-Guided Monitoring of Vancomycin and Its Impact on Nephrotoxicity: A Systematic Review and Meta-Analysis

AS Lim, SHW Foo, JJB Seng, TTM Ng… - Therapeutic Drug …, 2023 - journals.lww.com
Background: Conventionally, vancomycin trough levels have been used for therapeutic drug
monitoring (TDM). Owing to the increasing evidence of trough levels being poor surrogates …

Toxin-related acute kidney injury

P Albuquerque, G Meneses - Nephrology and Public Health Worldwide, 2021 - karger.com
Clinical Background: Nephrotoxic acute kidney injury or toxin-related acute kidney injury
(ToxAKI) is a relevant and relatively common category of kidney damage. Exogenous toxins …

Rapid monitoring of vancomycin concentration in serum using europium (III) chelate nanoparticle-based lateral flow immunoassay

L Bian, J Liang, H Zhao, K Ye, Z Li, T Liu, J Peng… - Frontiers in …, 2021 - frontiersin.org
Establishing personalized medication plans for patients to maximize therapeutic efficacy and
minimize the toxicity of vancomycin (VAN) requires rapid, simple, and accurate monitoring of …

[HTML][HTML] Evaluation of vancomycin TDM strategies: prediction and prevention of kidney injuries based on vancomycin TDM results

B Kim, S Hwang, E Heo, H Kim, J Jung… - Journal of Korean …, 2023 - synapse.koreamed.org
The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target
24-hour area under the curve (AUC 0-24) of 400 to 600 mg* h/L for serious methicillin …

[HTML][HTML] Vancomycin area under the curve and pharmacokinetic parameters during the first 24 hours of treatment in critically ill patients using Bayesian forecasting

M Pongchaidecha, D Changpradub… - Infection & …, 2020 - ncbi.nlm.nih.gov
Background Currently, the achievement of the target area under the curve (AUC)/minimum
inhibitory concentration ratio during the first 24-48 h of treatment is associated with reduced …

Vancomycin hydrochloride as a risk factor for acute kidney injury: a retrospective study

S Uekusa, Y Hanai, S Hirayama, T Yokoo… - Pharmacology, 2023 - karger.com
Introduction: The incidence of acute kidney injury (AKI) caused by vancomycin hydrochloride
(VCM) was reported to be 5–43%. VCM-induced AKI was reported to be more likely to occur …

A simple and rapid strategy for monitoring vancomycin concentration in serum using a multicolor immunosensor based on the ratio of gold nanobipyramids and a …

Y Fu, C Yang, C Liu, X Xu, Z Shi, D Jiang, D Yan - Analytical Methods, 2023 - pubs.rsc.org
Rapid and simple monitoring of vancomycin (VAN) concentration in blood is a vital strategy
for maximizing therapeutic efficacy, minimizing toxicity and developing a personalized …

Is It Still Beneficial to Monitor the Trough Concentration of Vancomycin? A Quantitative Meta-Analysis of Nephrotoxicity and Efficacy

W Yang, K Zhang, Y Chen, Y Fan, J Zhang - Antibiotics, 2024 - mdpi.com
This study conducted a quantitative meta-analysis to investigate the association of
vancomycin indicators, particularly area under the curve over 24 h (AUC24) and trough …

Pharmacokinetic/pharmacodynamic parameters of vancomycin for predicting clinical outcome of enterococcal bacteremia

E Nham, K Huh, YM Sohn, HJ Park, H Kim… - BMC Infectious …, 2022 - Springer
Purpose To find pharmacokinetic/pharmacodynamic parameters of vancomycin associated
with the optimal outcome of severe infection due to Enterococcus species. Methods We …

Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs

Y Guo, S Wang, P Li, P Zhang, W Wang - Sensors, 2023 - mdpi.com
Vancomycin (VAN), a glycopeptide antibiotic, is the preferred therapeutic agent for treating
Gram-positive bacteria. Rapid and precise quantification of VAN levels in cerebrospinal fluid …