Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …

Children with Down syndrome have a 10–20-fold elevated risk of developing leukemia,
particularly acute megakaryoblastic leukemia (AMKL) 1. While a subset of pediatric AMKLs …

Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, a key activator of
cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this …

Although much is understood about the ways in which transcription factors regulate various
differentiation systems, and one of the hallmarks of many human cancers is a lack of cellular …

Over the past year, vertebrate GATA factors have been found to participate directly in several
signal-transduction pathways. Smad3, phosphorylated by TGF-β signalling, interacts with …

The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

GATA‐1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and
mast cell lineages. It acts as an activator and repressor of different target genes, for example …

Acquired mutations in the hematopoietic transcription factor GATA binding protein-1
(GATA1) are found in megakaryoblasts from nearly all individuals with Down syndrome with …