Emerging roles of the MAGE protein family in stress response pathways
The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
Iron and lung cancer
Y Kuang, Q Wang - Cancer Letters, 2019 - Elsevier
Iron is an essential trace element in the human body, and its deficiency or excess induces
diverse biological processes. Iron dysregulation is closely associated with the initiation and …
diverse biological processes. Iron dysregulation is closely associated with the initiation and …
Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins
S Griffith-Jones, L Álvarez, U Mukhopadhyay… - The EMBO …, 2024 - embopress.org
MAGEA4 is a cancer-testis antigen primarily expressed in the testes but aberrantly
overexpressed in several cancers. MAGEA4 interacts with the RING ubiquitin ligase RAD18 …
overexpressed in several cancers. MAGEA4 interacts with the RING ubiquitin ligase RAD18 …
A cancer-specific ubiquitin ligase drives mRNA alternative polyadenylation by ubiquitinating the mRNA 3′ end processing complex
Alternative polyadenylation (APA) contributes to transcriptome complexity by generating
mRNA isoforms with varying 3′ UTR lengths. APA leading to 3′ UTR shortening (3′ US) …
mRNA isoforms with varying 3′ UTR lengths. APA leading to 3′ UTR shortening (3′ US) …
MAGE cancer-testis antigens protect the mammalian germline under environmental stress
K Fon Tacer, MC Montoya, MJ Oatley, T Lord… - Science …, 2019 - science.org
Ensuring robust gamete production even in the face of environmental stress is of utmost
importance for species survival, especially in mammals that have low reproductive rates …
importance for species survival, especially in mammals that have low reproductive rates …
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly
Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not
only initiate and maintain malignant phenotypes but also enhance therapeutic resistance …
only initiate and maintain malignant phenotypes but also enhance therapeutic resistance …
Targeting iron-sulfur clusters in cancer: opportunities and challenges for ferroptosis-based therapy
J Lee, JL Roh - Cancers, 2023 - mdpi.com
Simple Summary Iron-sulfur clusters (ISCs) play a crucial role in cancer cell survival and
growth, and their dysregulation is associated with the development and progression of …
growth, and their dysregulation is associated with the development and progression of …
Roles of the m6A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses
Purpose Glioblastoma multiforme (GBM) is a common and aggressive form of brain tumor.
The N6-methyladenosine (m6A) mRNA modification plays multiple roles in many biological …
The N6-methyladenosine (m6A) mRNA modification plays multiple roles in many biological …
Discovery and structural basis of the selectivity of potent cyclic peptide inhibitors of MAGE-A4
MC Fleming, LF Chiou, PP Tumbale… - Journal of medicinal …, 2022 - ACS Publications
MAGE proteins are cancer testis antigens (CTAs) that are characterized by highly conserved
MAGE homology domains (MHDs) and are increasingly being found to play pivotal roles in …
MAGE homology domains (MHDs) and are increasingly being found to play pivotal roles in …
[HTML][HTML] Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex
E Ibars, J Codina-Fabra, G Bellí, C Casas, M Tarrés… - Cell Reports, 2023 - cell.com
Ubiquitination controls numerous cellular processes, and its deregulation is associated with
many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with …
many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with …