Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

This review summarizes relevant studies concerning uric acid and possible links to
hypertension, renal disease, and cardiovascular disease. Whether uric acid is an …

Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly
considered a true risk factor. Recent studies suggest that uric acid is biologically active and …

OBJECTIVE Dapagliflozin, a highly selective inhibitor of the renal sodium-glucose
cotransporter-2, increases urinary excretion of glucose and lowers plasma glucose levels in …

Objective The role of serum uric acid as an independent risk factor for cardiovascular
disease remains unclear, although hyperuricemia is associated with cardiovascular disease …