[HTML][HTML] Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?
Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
Regulation of blood–brain barrier integrity by microglia in health and disease: a therapeutic opportunity
PT Ronaldson, TP Davis - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …
The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
[HTML][HTML] Neuroinflammation as a key driver of secondary neurodegeneration following stroke?
SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …
White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies
P Ballabh, LS de Vries - Nature Reviews Neurology, 2021 - nature.com
Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …
no specific or effective treatment. In the last two decades, much has been learned about the …
[HTML][HTML] Neurogenesis after stroke: a therapeutic perspective
Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …
available to treat stroke are very limited. There is an urgent need to develop novel …
[HTML][HTML] Targeting necroptosis: a novel therapeutic option for retinal degenerative diseases
Q Zhang, X Hu, W Zhao, X Ban, Y Li… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …
Filling the gaps on stroke research: Focus on inflammation and immunity
D Levard, I Buendia, A Lanquetin, M Glavan… - Brain, behavior, and …, 2021 - Elsevier
For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …
[HTML][HTML] Potential neuroprotective treatment of stroke: targeting excitotoxicity, oxidative stress, and inflammation
Q Yang, Q Huang, Z Hu, X Tang - Frontiers in neuroscience, 2019 - frontiersin.org
Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …