Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

The brain is composed of multiple regions associated with distinct functions, which have
become further specialized in the human lineage. To define how this specialization is …

From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …

The development of highly parallel and affordable high-throughput single-cell
transcriptomics technologies has revolutionized our understanding of brain complexity …

The mammalian brain is composed of many brain structures, each with its own ontogenetic
and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 …

Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the
brain. Yet little is understood about how genetic variants influence cell-level gene …

Single-cell technologies have enhanced comprehensive knowledge regarding the human
brain by facilitating an extensive transcriptomic census across diverse brain regions …

In spite of major efforts and investment in development of psychiatric drugs, many clinical
trials have failed in recent decades, and clinicians still prescribe drugs that were discovered …

Neuroscience research has entered a phase of key discoveries in the realm of
neurogenomics owing to strong financial and intellectual support for resource building and …

Alzheimer's disease (AD) is a neurodegenerative disease with a projected significant
increase in incidence. Therefore, this study analyzed single-nucleus AD data to provide a …