Role of insulin in health and disease: an update
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …
Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer
JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …
hyperinsulinemia. However, recent data suggest a reverse order and place …
Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Z Xie, Y Sun, Y Ye, D Hu, H Zhang, Z He… - Nature …, 2022 - nature.com
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …
[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
[HTML][HTML] Insulin resistance
AM Freeman, N Pennings - 2018 - europepmc.org
Objectives: Articulate the acquired and genetic causes of insulin resistance. Explain the
pathophysiology of insulin resistance. Summarize the 3 arms in the management of insulin …
pathophysiology of insulin resistance. Summarize the 3 arms in the management of insulin …
[HTML][HTML] Redox changes in obesity, metabolic syndrome, and diabetes
Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …
Insulin: too much of a good thing is bad
H Kolb, K Kempf, M Röhling, S Martin - BMC medicine, 2020 - Springer
Background Insulin shares a limited physiological concentration range with other endocrine
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …
Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric …
R Chakraborty, S Roy - Journal of Integrative Medicine, 2021 - Elsevier
Angiotensin-converting enzyme (ACE) inhibitors are antihypertensive medications often
used in the treatment of diabetes-related complications. Synthetic ACE inhibitors are known …
used in the treatment of diabetes-related complications. Synthetic ACE inhibitors are known …
Obesity and cancer metastasis: molecular and translational perspectives
Simple Summary A major challenge in treating cancer is when the cancer spreads from its
original site to other parts of the body, a process also known as metastasis. In order to …
original site to other parts of the body, a process also known as metastasis. In order to …
[HTML][HTML] Equine metabolic syndrome: role of the enteroinsular axis in the insulin response to oral carbohydrate
MA de Laat, DM Fitzgerald - The Veterinary Journal, 2023 - Elsevier
Equine insulin dysregulation (ID) comprises amplified insulin responses to oral
carbohydrates or insulin resistance, or both, which leads to sustained or periodic …
carbohydrates or insulin resistance, or both, which leads to sustained or periodic …