Role of insulin in health and disease: an update

MS Rahman, KS Hossain, S Das, S Kundu… - International journal of …, 2021 - mdpi.com
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer

JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Z Xie, Y Sun, Y Ye, D Hu, H Zhang, Z He… - Nature …, 2022 - nature.com
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …

[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer

AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

[HTML][HTML] Insulin resistance

AM Freeman, N Pennings - 2018 - europepmc.org
Objectives: Articulate the acquired and genetic causes of insulin resistance. Explain the
pathophysiology of insulin resistance. Summarize the 3 arms in the management of insulin …

[HTML][HTML] Redox changes in obesity, metabolic syndrome, and diabetes

B Korac, A Kalezic, V Pekovic-Vaughan, A Korac… - Redox Biology, 2021 - Elsevier
Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …

Insulin: too much of a good thing is bad

H Kolb, K Kempf, M Röhling, S Martin - BMC medicine, 2020 - Springer
Background Insulin shares a limited physiological concentration range with other endocrine
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …

Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric …

R Chakraborty, S Roy - Journal of Integrative Medicine, 2021 - Elsevier
Angiotensin-converting enzyme (ACE) inhibitors are antihypertensive medications often
used in the treatment of diabetes-related complications. Synthetic ACE inhibitors are known …

Obesity and cancer metastasis: molecular and translational perspectives

S Annett, G Moore, T Robson - Cancers, 2020 - mdpi.com
Simple Summary A major challenge in treating cancer is when the cancer spreads from its
original site to other parts of the body, a process also known as metastasis. In order to …

[HTML][HTML] Equine metabolic syndrome: role of the enteroinsular axis in the insulin response to oral carbohydrate

MA de Laat, DM Fitzgerald - The Veterinary Journal, 2023 - Elsevier
Equine insulin dysregulation (ID) comprises amplified insulin responses to oral
carbohydrates or insulin resistance, or both, which leads to sustained or periodic …