[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications
WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …
because of their high immunomodulation ability, tropism towards inflamed and injured …
Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on …
S Viswanathan, Y Shi, J Galipeau, M Krampera… - Cytotherapy, 2019 - Elsevier
Abstract The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal
Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of …
Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of …
Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …
applications have greatly diversified during the past decade, including rapid growth of poorly …
Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics
C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …
procedures–short “freeze-thawing”–are among the final steps in economically viable …
Manufacturing of primed mesenchymal stromal cells for therapy
JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …
manufactured and developed as unique cell products by many different manufacturers and …
Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial …
J Chahal, A Gómez-Aristizábal… - Stem cells …, 2019 - academic.oup.com
Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-
articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) …
articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) …