In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

Dendritic structure critically determines the electrical properties of neurons and, thereby,
defines the fundamental process of input-to-output conversion. The diversity of dendritic …

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to
be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short …

Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than
previously believed. Several studies report spontaneous seizures and interictal discharges …

Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …

Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the
leading cause of dementia worldwide, and is characterized by the accumulation of amyloid …

Epilepsy is a comorbidity associated with Alzheimer's disease (AD), often starting many
years earlier than memory decline. Investigating this association in the early pre …

Although the anterior cingulate cortex (ACC) plays a vital role in neuropathic pain-related
aversion, the underlying mechanisms haven't been fully studied. The mesolimbic dopamine …