Chiral molecules with multiple stereocenters are widely present in natural products and
pharmaceuticals, whose absolute and relative configurations are both critically important for …

Computational analyses have revealed that the distortion of a catalyst and the substrates
and their interactions are key to determining the stability of the transition state. Hence, two …

An exo-selective Diels–Alder (exo-DA) reaction in which the formed diastereomer is different
from that formed in the conventional endo-selective Diels–Alder (endo-DA) reaction was …

The dynamic parallel kinetic resolution (DPKR) of an α-ferrocenyl cation intermediate under
the influence of a chiral conjugate base of a chiral phosphoric acid catalyst has been …

Computational studies of chiral phosphoric acid (CPA)-catalyzed dynamic kinetic
asymmetric hydroamination (DyKAH) of racemic allenes show that the reaction proceeds …

An efficient method for the synthesis of chiral tetrahydrocarbazoles (THCs) containing an
allene moiety is disclosed, which was established by an enantioconvergent substitution …

Theoretical calculations, associated with control experiments, were carried out to gain
insights into the mechanism and origin of enantioselectivity in the phosphoric-acid-catalyzed …

The full mechanism of the asymmetric α‐thiolation of azlactones catalyzed by a cinchona
alkaloid‐derived squaramide was carefully investigated through theoretical calculations …