Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
W Hu, Y Chen, C Dou, S Dong - Annals of the Rheumatic Diseases, 2021 - ard.bmj.com
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …
considered as primarily a disease of the articular cartilage, the participation of subchondral …
Cartilage calcification in osteoarthritis: mechanisms and clinical relevance
I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …
observed both at the cartilage surface and in its deeper layers. The formation of calcium …
Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression
G Musumeci, FC Aiello, MA Szychlinska… - International journal of …, 2015 - mdpi.com
Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than
half of the over 65 population. In the past, OA was considered a wear and tear disease …
half of the over 65 population. In the past, OA was considered a wear and tear disease …
Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis
G Musumeci, P Castrogiovanni, FM Trovato… - International journal of …, 2015 - mdpi.com
Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …
Minimally invasive and regenerative therapeutics
Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging,
microsurgery procedures, and microscale technologies have made minimally invasive …
microsurgery procedures, and microscale technologies have made minimally invasive …
[HTML][HTML] ER stress-induced cell death in osteoarthritic cartilage
Y Rellmann, E Eidhof, R Dreier - Cellular signalling, 2021 - Elsevier
In cartilage, chondrocytes are responsible for the biogenesis and maintenance of the
extracellular matrix (ECM) composed of proteins, glycoproteins and proteoglycans. Various …
extracellular matrix (ECM) composed of proteins, glycoproteins and proteoglycans. Various …
[HTML][HTML] Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis
Aging and inflammation are major contributing factors to the development and progression
of arthritic and musculoskeletal diseases.“Inflammaging” refers to low-grade inflammation …
of arthritic and musculoskeletal diseases.“Inflammaging” refers to low-grade inflammation …
Exercise for osteoarthritis: a literature review of pathology and mechanism
H Kong, XQ Wang, XA Zhang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Osteoarthritis (OA) has a very high incidence worldwide and has become a very common
joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug …
joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug …
MicroRNAs and osteoarthritis
CJ Malemud - Cells, 2018 - mdpi.com
An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic
pathways toward the latter causes an aberrant turnover and loss of extracellular matrix …
pathways toward the latter causes an aberrant turnover and loss of extracellular matrix …
Study on the effect of reactive oxygen species-mediated oxidative stress on the activation of mitochondrial apoptosis and the tenderness of yak meat
LL Wang, QL Yu, L Han, XL Ma, RD Song, SN Zhao… - Food Chemistry, 2018 - Elsevier
This study investigated the effect of reactive oxygen species-mediated oxidative stress on
activation of mitochondrial apoptosis and tenderness of yak meat during postmortem ageing …
activation of mitochondrial apoptosis and tenderness of yak meat during postmortem ageing …