The role of caspase proteases in regulated processes such as apoptosis and inflammation
has been studied for more than two decades, and the activation cascades are known in …

Protein inhibitors of proteases are an important tool of nature to regulate and control
proteolysis in living organisms under physiological and pathological conditions. In this …

Clostridium difficile infection (CDI) is a major nosocomial disease associated with significant
morbidity and mortality. The pathology of CDI stems primarily from the 2 C. difficile–secreted …

Multivalent binding proteins can gain biological activities beyond what is inherent in the
individual binders, by bringing together different target molecules, restricting their …

Nonimmunoglobulin scaffolds have been developed to overcome the limitations of
monoclonal antibodies with regard to stability and size. Of these scaffolds, the class of …

Objective: This study aimed to investigate methodologies for the extraction and purification
of polysaccharides from Rosa roxburghii Tratt fruits and their impact on various cellular …

The paper investigates the relationship between pro-social norms and its implications for
improved environmental outcomes. This is an area, which has been neglected in the …

Apoptosis is an important antiviral host defense mechanism. Here we report the
identification of a novel apoptosis inhibitor encoded by the vaccinia virus (VACV) M1L gene …

Background: Antibodies constitute an important drug development platform for drugs to treat
several ophthalmic, oncologic, and immunologic conditions, but due to limitations inherent in …

Cancer is frequently characterised by dysregulation of the cellular signalling processes that
govern proliferation, survival and attachment. Understanding such dysregulation continues …