Actin is a widely expressed protein found in almost all eukaryotic cells. In humans, there are
six different genes, which encode specific actin isoforms. Disease-causing mutations have …

Advances in screening and computational methods have enhanced recent efforts to
discover/design small-molecule protein inhibitors. One attractive target for inhibition is the …

The interaction of myosin with actin filaments is the central feature of muscle contraction and
cargo movement along actin filaments of the cytoskeleton. The energy for these movements …

Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a rare disorder of
enteric smooth muscle function affecting the intestine and bladder. Patients with this severe …

The assembly of actin monomers into filaments and networks plays vital roles throughout
eukaryotic biology, including intracellular transport, cell motility, cell division, determining …

Despite their near sequence identity, actin isoforms cannot completely replace each other in
vivo and show marked differences in their tissue-specific and subcellular localization. Little …

Various heterozygous cytoskeletal γ-actin mutations have been shown to cause Baraitser–
Winter cerebrofrontofacial syndrome, non-syndromic hearing loss, or isolated eye coloboma …

Thymosin β4 (Tβ4), a multifunctional 44-amino acid polypeptide and a member of actin-
binding proteins (ABPs), plays an important role in developmental processes and wound …

Mutations in the cardiac actin gene (ACTC1) are associated with the development of
hypertrophic cardiomyopathy (HCM). To date, 12 different ACTC1 mutations have been …

Actin assembly, filament mechanical properties, and interactions with regulatory proteins
depend on the types and concentrations of salts in solution. Salts modulate actin through …