Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Vitamin D and its active metabolites are important nutrients for human skeletal health. UV
irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the …

Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent
kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …

A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …

Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic
retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases …

Cellular feedback systems ensure genome maintenance during DNA replication. When
replication forks stall, newly replicated DNA is protected by pathways that limit excessive …