Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Background Microglial-mediated neuroinflammation plays an important role in vascular
dementia, and modulating neuroinflammation has emerged as a promising treatment target …

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The
NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms …

Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …

Antifragile is a standalone book in Nassim Nicholas Taleb's landmark Incerto series, an
investigation of opacity, luck, uncertainty, probability, human error, risk, and decision-making …

Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …