The mammary gland in adult women consists of biologically distinct cell types that differ in
their surface phenotypes. Isolation and molecular characterization of these subpopulations …

The proto-oncogene Myc serves as a paradigm for understanding the dynamics of
transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer …

ATRis an attractive target in cancer therapy because it signals replication stress and DNA
lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage …

Cancer cells can upregulate the MYC expression to repair the radiotherapy‐triggered DNA
damage, aggravating therapeutic resistance and tumor immunosuppression. Epigenetic …

PTEN deficiency often causes defects in DNA damage repair. Currently, effective therapies
for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous …

Background RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif
(RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming …

Radiotherapy effectiveness in breast cancer is limited by radioresistance. Nevertheless, the
mechanisms behind radioresistance are not yet fully understood. RUVBL1 and RUVBL2 …

The initiation and progression of breast cancer from the transformation of the normal
epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process …

Deregulation of c-Myc often occurs in various human cancers, which not only contributes to
the genesis and progression of cancers but also affects the outcomes of cancer radio-or …

Brain tumors are the second most common group of childhood cancers, accounting for about
20%–25% of all pediatric tumors. Deregulated expression of the MYC family of transcription …