Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer
D Pellacani, S Tan, S Lefort, CJ Eaves - The EMBO journal, 2019 - embopress.org
The mammary gland in adult women consists of biologically distinct cell types that differ in
their surface phenotypes. Isolation and molecular characterization of these subpopulations …
their surface phenotypes. Isolation and molecular characterization of these subpopulations …
Is Myc an important biomarker? Myc expression in immune disorders and cancer
S Trop-Steinberg, Y Azar - The American journal of the medical sciences, 2018 - Elsevier
The proto-oncogene Myc serves as a paradigm for understanding the dynamics of
transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer …
transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer …
[HTML][HTML] Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition
FK Middleton, MJ Patterson, CJ Elstob, S Fordham… - Oncotarget, 2015 - ncbi.nlm.nih.gov
ATRis an attractive target in cancer therapy because it signals replication stress and DNA
lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage …
lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage …
Dual‐Epigenetically Relieving the MYC‐Correlated Immunosuppression via an Advanced Nano‐Radiosensitizer Potentiates Cancer Immuno‐Radiotherapy
Cancer cells can upregulate the MYC expression to repair the radiotherapy‐triggered DNA
damage, aggravating therapeutic resistance and tumor immunosuppression. Epigenetic …
damage, aggravating therapeutic resistance and tumor immunosuppression. Epigenetic …
ATM inhibition induces synthetic lethality and enhances sensitivity of PTEN-deficient breast cancer cells to cisplatin
K Li, H Yan, W Guo, M Tang, X Zhao, A Tong… - Experimental cell …, 2018 - Elsevier
PTEN deficiency often causes defects in DNA damage repair. Currently, effective therapies
for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous …
for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous …
The role of c-Myc-RBM38 loop in the growth suppression in breast cancer
XX Li, L Shi, XJ Zhou, J Wu, TS Xia, WB Zhou… - Journal of Experimental …, 2017 - Springer
Background RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif
(RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming …
(RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming …
RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast …
J Tian, M Wen, P Gao, M Feng, G Wei - Cell Death & Disease, 2024 - nature.com
Radiotherapy effectiveness in breast cancer is limited by radioresistance. Nevertheless, the
mechanisms behind radioresistance are not yet fully understood. RUVBL1 and RUVBL2 …
mechanisms behind radioresistance are not yet fully understood. RUVBL1 and RUVBL2 …
Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model
The initiation and progression of breast cancer from the transformation of the normal
epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process …
epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process …
The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity
F Cui, R Fan, Q Chen, Y He, M Song, Z Shang… - Molecular and cellular …, 2015 - Springer
Deregulation of c-Myc often occurs in various human cancers, which not only contributes to
the genesis and progression of cancers but also affects the outcomes of cancer radio-or …
the genesis and progression of cancers but also affects the outcomes of cancer radio-or …
Modeling and Targeting MYC Genes in Childhood Brain Tumors
S Hutter, S Bolin, H Weishaupt, FJ Swartling - Genes, 2017 - mdpi.com
Brain tumors are the second most common group of childhood cancers, accounting for about
20%–25% of all pediatric tumors. Deregulated expression of the MYC family of transcription …
20%–25% of all pediatric tumors. Deregulated expression of the MYC family of transcription …