Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate
one-carbon metabolism. MS is a large multi-domain protein capable of binding and …

Vitamin B12 (cobalamin) is an essential nutrient for humans and animals. Metabolically
active forms of B12-methylcobalamin and 5-deoxyadenosylcobalamin are cofactors for the …

Cobalt–sulfur (Co–S) coordination is labile to both oxidation and reduction chemistry and is
rarely seen in nature. Cobalamin (or vitamin B12) is an essential cobalt-containing …

Abstract Transglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has
been investigated as a therapeutic target for Celiac disease, neurological disorders, and …

Oxygen-sensitive metalloenzymes are responsible for many of the most fundamental
biochemical processes in nature, from the reduction of dinitrogen in nitrogenase to the …

Although protein-based fibers have been developed, the preparation of inexpensive, safe
and environmentally friendly plant protein fibers is still a hot topic. Herein, we constructed …

Multidomain proteins that engage in conformational acrobatics in service of their cellular
functions are typically challenging candidates for structure elucidation. Depending on the …

G-proteins function as molecular switches to power cofactor translocation and confer fidelity
in metal trafficking. The G-protein, MMAA, together with MMAB, an adenosyltransferase …

Although protein-based biomimetic fibers are available, green and inexpensive protein-
based fibers remain a challenge to develop. Herein, a microfluidic chip was designed to …

Efficient and high-accuracy filtering of cryo-electron microscopy (cryo-EM) micrographs is an
emerging challenge with the growing speed of data collection and sizes of datasets …