Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens,
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …

The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …

Challenges in drug development of neurological diseases remain mainly ascribed to the
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …

The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …

Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB)
remains a formidable challenge for central nervous system drug development. High‐fidelity …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

Neurovascular inflammation is a major contributor to many neurological disorders, but
modeling these processes in vitro has proven to be difficult. Here, we microengineered a …

Abstract Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation
of in vivo cell-cell and cell-extracellular matrix interactions than conventional two …