Since coumarin and hydroxamic acid compounds are well-known in medicinal chemistry, a
variety of their derivatives have been highlighted due to their potential uses for plentiful …

Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …

Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the
potential to affect vision, and can even be fatal in some children. While the tumor can be …

Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half of
patients will develop distant metastasis after CRC resection, usually with very poor …

Multi-targeted agents can interact with multiple targets sequentially, resulting in synergistic
and more effective therapies for several complicated disorders, including cancer, even with …

A series of novel coumarin-based hydroxamate derivatives were designed and synthesized
as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC …

Abstract MicroRNA‑936 (miR‑936) has been reported to play important roles in the
progression of non‑small cell lung cancer and glioma. However, the expression and …

Pyrrole is a biologically active scaffold, which itself possess noticeable anticancer activity
against several types of cancer specially leukemia, lymphoma, and myelofibrosis. SAHA and …

Microtubules, one of the cytoskeletons in eukaryotic cells, maintain the proper operation of
several cellular functions. Additionally, they are regulated by the acetylation of HDAC6 and …

Epigenetic dysregulation is an important feature of colorectal cancer (CRC). Combining
epigenetic drugs with other antineoplastic agents is a promising treatment strategy for …