Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

It was first demonstrated in the late nineteenth century that human deaths from fever were
typically due to infections. As the germ theory gained ground, it replaced the old, unproven …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

Human papillomaviruses (HPVs) cause a range of serious diseases, including the vast
majority of cervical cancers, most anal cancers and around half of head and neck cancers …

The beta genus comprises more than 50 beta human papillomavirus (HPV) types that are
suspected to be involved, together with ultraviolet (UV) irradiation, in the development of non …