Immunotherapies have emerged as one of the most promising approaches to treat patients
with cancer. Recently, there have been many clinical successes using checkpoint receptor …

Phaeochromocytomas and paragangliomas (PPGLs) are neural-crest-derived tumours of
the sympathetic or parasympathetic nervous system that are often inherited and are …

Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here
we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell …

As more clinically relevant cancer genes are identified, comprehensive diagnostic
approaches are needed to match patients to therapies, raising the challenge of optimization …

Background Although high-throughput sequencing, such as Illumina-based technologies
(eg MiSeq), has revolutionized microbial ecology, adaptation of amplicon sequencing for …

Next-generation sequencing (NGS) has enabled genome-wide personalized oncology
efforts at centers and companies with the specialty expertise and infrastructure required to …

One-hundred-fifty-three biliary cancers, including 70 intrahepatic cholangiocarcinomas
(ICC), 57 extrahepatic cholangiocarcinomas (ECC) and 26 gallbladder carcinomas (GBC) …

The implementation of cancer genomic testing into the clinical setting has brought major
opportunities. However, as our understanding of cancer initiation, maintenance and …

Background “Diffuse midline glioma (DMG), H3 K27M-mutant” is a new tumor entity
established in the 2016 WHO classification of Tumors of the Central Nervous System that …

Background: Next generation sequencing (NGS)-based multi-gene panel tests have been
performed to predict the treatment response and prognosis in patients with colorectal cancer …