Applications of ion mobility-mass spectrometry in carbohydrate chemistry and glycobiology
Carbohydrate analyses are often challenging due to the structural complexity of these
molecules, as well as the lack of suitable analytical tools for distinguishing the vast number …
molecules, as well as the lack of suitable analytical tools for distinguishing the vast number …
Navigate flying molecular elephants safely to the ground: mass-selective soft landing up to the Mega-Dalton range by Electrospray Controlled Ion-Beam Deposition
A Walz, K Stoiber, A Huettig, H Schlichting… - Analytical …, 2022 - ACS Publications
The prototype of a highly versatile and efficient preparative mass spectrometry system used
for the deposition of molecules in ultrahigh vacuum (UHV) is presented, along with …
for the deposition of molecules in ultrahigh vacuum (UHV) is presented, along with …
Binding Selectivity of Methanobactin from Methylosinus trichosporium OB3b for Copper(I), Silver(I), Zinc(II), Nickel(II), Cobalt(II), Manganese(II), Lead(II), and Iron(II)
Methanobactin (Mb) from Methylosinus trichosporium OB3b is a member of a class of metal
binding peptides identified in methanotrophic bacteria. Mb will selectively bind and reduce …
binding peptides identified in methanotrophic bacteria. Mb will selectively bind and reduce …
Expanding Orbitrap Collision Cross-Section Measurements to Native Protein Applications Through Kinetic Energy and Signal Decay Analysis
The measurement of collision cross sections (CCS, σ) offers supplemental information about
sizes and conformations of ions beyond mass analysis alone. We have previously shown …
sizes and conformations of ions beyond mass analysis alone. We have previously shown …
Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein
EM Martin, FDL Kondrat, AJ Stewart, JH Scrivens… - Scientific reports, 2018 - nature.com
Zinc modulates the biological function of histidine-rich glycoprotein (HRG) through binding
to its His-rich region (HRR). The Zn2+-binding properties of a 35 amino-acid biologically …
to its His-rich region (HRR). The Zn2+-binding properties of a 35 amino-acid biologically …
Weak acid-base interactions of histidine and cysteine affect the charge states, tertiary structure, and Zn (II)-binding of heptapeptides
YF Lin, EN Yousef, E Torres, L Truong… - Journal of The …, 2019 - ACS Publications
Zinc fingers are proteins that are characterized by the coordination of zinc ions by an amino
acid sequence that commonly contains two histidines and two cysteines (2His-2Cys motif) …
acid sequence that commonly contains two histidines and two cysteines (2His-2Cys motif) …
Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies
Insulin formulations with diverse oligomerization states are the hallmark of interventions for
the treatment of diabetes. Here using single-molecule recordings we firstly reveal that insulin …
the treatment of diabetes. Here using single-molecule recordings we firstly reveal that insulin …
Direct dynamics simulations of fragmentation of a Zn (II)-2Cys-2His oligopeptide. Comparison with mass spectrometry collision-induced dissociation
A Malik, YF Lin, S Pratihar, LA Angel… - The Journal of Physical …, 2019 - ACS Publications
Abnormalities in zinc metabolism have been linked to many diseases, including different
kinds of cancers and neurological diseases. The present study investigates the …
kinds of cancers and neurological diseases. The present study investigates the …
pH dependent chelation study of Zn (II) and Ni (II) by a series of hexapeptides using electrospray ionization–Ion mobility–Mass spectrometry
AB Ilesanmi, TC Moore, LA Angel - International Journal of Mass …, 2020 - Elsevier
Presented here are the results of a study characterizing the selective metal chelating
performance of the alternative metal binding (amb) peptide: acetyl-His 1-Cys 2-Gly 3-Pro 4 …
performance of the alternative metal binding (amb) peptide: acetyl-His 1-Cys 2-Gly 3-Pro 4 …
ESI-IM-MS reveals the metal binding of three analog methanobactin peptides with different numbers of free Cys at physiological pH
R Vangala, LA Angel - International Journal of Mass Spectrometry, 2021 - Elsevier
Three analog methanobactin (amb 7) peptides containing the primary structure acetyl-Leu 1-
His 2-Cys 3-Gly 4-Ser 5-Cys 6-Tyr 7-Pro 8-His 9-Cys 10-Ser 11-Cys 12-Met 13 but differing …
His 2-Cys 3-Gly 4-Ser 5-Cys 6-Tyr 7-Pro 8-His 9-Cys 10-Ser 11-Cys 12-Met 13 but differing …