Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …

Phenomics, the complexity of microglia phenotypes and their related functions compels the
continuous study of microglia in disease animal models to find druggable targets for …

Structural, functional, and molecular reorganization of denervated neural networks is often
observed in neurological conditions. The loss of input is accompanied by homeostatic …

Background During aging, both the brain and the immune system undergo a progressive
impairment of physiological functions. Microglia, the immunocompetent cells of the central …

Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous
system (CNS). They influence neuronal functions and circuit activities with effects on …

Introduction: The gut microbiota (MB), although one of the main producers of Aβ in the body,
in physiological conditions contributes to the maintainance of a healthy brain. Dysbiosis, the …

Chronic neuropathic pain precipitates a complex range of affective and behavioural
disturbances that differ markedly between individuals. While the reasons for differences in …

Pregnancy and motherhood can have long-term effects on cognition and brain aging in both
humans and rodents. Estrogens are related to cognitive function and neuroplasticity …

Microglia are innate CNS immune cells that play key roles in supporting key CNS functions
including brain plasticity. We now report a previously unknown role for microglia in …

Microglia and neurons live physically intertwined, intimately related structurally and
functionally in a dynamic relationship in which microglia change continuously over a much …