[HTML][HTML] Microglial transcriptional signatures in the central nervous system: Toward a future of unraveling their function in health and disease
HA Vecchiarelli, MÈ Tremblay - Annual Review of Genetics, 2023 - annualreviews.org
Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …
derived from the embryonic yolk sac and make their way to the CNS during early …
[HTML][HTML] Phenomic microglia diversity as a druggable target in the hippocampus in neurodegenerative diseases
D Lana, G Magni, E Landucci, GL Wenk… - International Journal of …, 2023 - mdpi.com
Phenomics, the complexity of microglia phenotypes and their related functions compels the
continuous study of microglia in disease animal models to find druggable targets for …
continuous study of microglia in disease animal models to find druggable targets for …
[HTML][HTML] Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion
M Lenz, A Eichler, P Kruse, P Stöhr… - Frontiers in Molecular …, 2023 - frontiersin.org
Structural, functional, and molecular reorganization of denervated neural networks is often
observed in neurological conditions. The loss of input is accompanied by homeostatic …
observed in neurological conditions. The loss of input is accompanied by homeostatic …
BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult mice
A Rinaldi, M Balietti, E Principi, M De Luca… - Brain, Behavior, and …, 2024 - Elsevier
Background During aging, both the brain and the immune system undergo a progressive
impairment of physiological functions. Microglia, the immunocompetent cells of the central …
impairment of physiological functions. Microglia, the immunocompetent cells of the central …
[HTML][HTML] Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice
MA Di Castro, S Garofalo, A Mormino… - Brain, Behavior, and …, 2024 - Elsevier
Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous
system (CNS). They influence neuronal functions and circuit activities with effects on …
system (CNS). They influence neuronal functions and circuit activities with effects on …
[HTML][HTML] Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer's disease in a APP/PS1 transgenic mouse model
D Lana, C Traini, I Bulli, G Sarti, G Magni… - Frontiers in …, 2024 - frontiersin.org
Introduction: The gut microbiota (MB), although one of the main producers of Aβ in the body,
in physiological conditions contributes to the maintainance of a healthy brain. Dysbiosis, the …
in physiological conditions contributes to the maintainance of a healthy brain. Dysbiosis, the …
[HTML][HTML] Minocycline abrogates individual differences in nerve injury-evoked affective disturbances in male rats and prevents associated supraspinal …
JA O'Brien, PJ Austin - Journal of Neuroimmune Pharmacology, 2024 - Springer
Chronic neuropathic pain precipitates a complex range of affective and behavioural
disturbances that differ markedly between individuals. While the reasons for differences in …
disturbances that differ markedly between individuals. While the reasons for differences in …
[HTML][HTML] Pregnancy history and estradiol influence spatial memory, hippocampal plasticity, and inflammation in middle-aged rats
Pregnancy and motherhood can have long-term effects on cognition and brain aging in both
humans and rodents. Estrogens are related to cognitive function and neuroplasticity …
humans and rodents. Estrogens are related to cognitive function and neuroplasticity …
[HTML][HTML] Microglia regulate motor neuron plasticity via reciprocal fractalkine/adenosine signaling
AB Marciante, A Tadjalli, KA Burrowes, JR Oberto… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Microglia are innate CNS immune cells that play key roles in supporting key CNS functions
including brain plasticity. We now report a previously unknown role for microglia in …
including brain plasticity. We now report a previously unknown role for microglia in …
Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions
AL Karperien, HF Jelinek - The Fractal Geometry of the Brain, 2024 - Springer
Microglia and neurons live physically intertwined, intimately related structurally and
functionally in a dynamic relationship in which microglia change continuously over a much …
functionally in a dynamic relationship in which microglia change continuously over a much …