Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human …

Persistent hair loss is a major cause of psychological distress and compromised quality of
life in millions of people worldwide. Remarkable progress has been made in understanding …

After severe heart injury, fibroblasts are activated and proliferate excessively to form
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …

Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury
repair, however, the roles of MSC-Ex in skin damage repair and its mechanisms are largely …