Aims To re‐examine various aspects of the benzodiazepines (BZDs), widely prescribed for
50 years, mainly to treat anxiety and insomnia. It is a descriptive review based on the Okey …

Benzodiazepine dependence could be prevented by adherence to recommendations for
short-term prescribing (2–4 weeks only when possible). Withdrawal of benzodiazepines …

Neurons in the arcuate nucleus that produce AgRP, NPY, and GABA (AgRP neurons)
promote feeding. Ablation of AgRP neurons in adult mice results in Fos activation in …

Discovered in the late 1950s by Leo Sternbach, the first benzodiazepine (BZD)
chlordiazepoxide was followed by several congeners, which rapidly constituted one of the …

The British Association for Psychopharmacology guidelines for the treatment of substance
abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on …

The use of benzodiazepine anxiolytics and hypnotics continues to excite controversy. Views
differ from expert to expert and from country to country as to the extent of the problem, or …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Background Prolonged treatment with benzodiazepines is common practice despite clinical
recommendations of short‐term use. Benzodiazepines are used by approximately 4% of the …

Globally benzodiazepines remain one of the most prescribed medication groups, especially
in the primary care setting. With such high levels of prescribing it is not surprising that …

BackgroundThe prevalence of benzodiazepine consumption in European countries remains
at 2–3% of the general population despite the well-documented disadvantages of long-term …