[HTML][HTML] COVID-19 and cancer comorbidity: therapeutic opportunities and challenges

AS Pathania, P Prathipati, BAA Abdul, S Chava… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory …

[HTML][HTML] Everything old is new again: drug repurposing approach for non-small cell lung cancer targeting MAPK signaling pathway

AS Jain, A Prasad, S Pradeep, C Dharmashekar… - Frontiers in …, 2021 - frontiersin.org
Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …

Drug repurposing: A strategy for discovering inhibitors against emerging viral infections

IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …

[HTML][HTML] A computational approach identified andrographolide as a potential drug for suppressing COVID-19-induced cytokine storm

M Rehan, F Ahmed, SM Howladar, MY Refai… - Frontiers in …, 2021 - frontiersin.org
Background The newly identified betacoronavirus SARS-CoV-2 is the causative pathogen of
the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now …

Status and prospect of novel treatment options toward alveolar and cystic echinococcosis

S Wang, Y Ma, W Wang, Y Dai, H Sun, J Li, S Wang… - Acta Tropica, 2022 - Elsevier
Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are the two most important
global parasitic infectious diseases caused by species of Echinococcus granulosus and E …

[HTML][HTML] Drug repurposing: Iron in the fire for older drugs

HV Sonaye, RY Sheikh, CA Doifode - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Repositioning or" repurposing" of existing therapies for indications of alternative disease is
an attractive approach that can generate lower costs and require a shorter approval time …

A hierarchical convolutional model for biomedical relation extraction

Y Hu, Y Chen, R Huang, Y Qin, Q Zheng - Information Processing & …, 2024 - Elsevier
Biomedical relation extraction aims to extract the interactive relations between biomedical
entities in a sentence. In biomedical literature, the sentence lengths are longer compared to …

Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function

H Li, R Zhang, Y Hu, J Li, Y Yang, D Wu, X Gu… - International …, 2023 - Elsevier
Liver fibrosis can progress to cirrhosis and hepatocellular carcinoma, which may eventually
lead to liver failure and even death. No direct anti-fibrosis drugs are available at present …

High-throughput screening for drug discovery targeting the cancer cell-microenvironment interactions in hematological cancers

AK Giri, A Ianevski - Expert opinion on drug discovery, 2022 - Taylor & Francis
Introduction The interactions between leukemic blasts and cells within the bone marrow
environment affect oncogenesis, cancer stem cell survival, as well as drug resistance in …

Recent advances in the development of thalidomide-related compounds as anticancer drugs

A Barbarossa, D Iacopetta, MS Sinicropi… - Current Medicinal …, 2022 - ingentaconnect.com
Introduction: Thalidomide is an old well-known drug firstly used as morning sickness relief in
pregnant women and then withdrawn from the market due to its severe side effects on fetal …