[HTML][HTML] Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials

JH Kim, KA Jenrow, SL Brown - Radiation oncology journal, 2014 - ncbi.nlm.nih.gov
To summarize current knowledge regarding mechanisms of radiation-induced normal tissue
injury and medical countermeasures available to reduce its severity. Advances in radiation …

Understanding the mechanism of radiation induced fibrosis and therapy options

A Ejaz, JS Greenberger, PJ Rubin - Pharmacology & therapeutics, 2019 - Elsevier
Radiation therapy has been increasingly employed as a tool to cure and palliate majority of
solid tumors. Although radiotherapy has shown promising results in preserving structure and …

Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive …

CH Kim, W Wu, M Wysoczynski, A Abdel-Latif… - Leukemia, 2012 - nature.com
We have observed that conditioning for hematopoietic transplantation by lethal irradiation
induces a proteolytic microenvironment in the bone marrow (BM) that activates the …

Mechanisms of radiation-induced skin injury and implications for future clinical trials

JH Kim, AJJ Kolozsvary, KA Jenrow… - International journal of …, 2013 - Taylor & Francis
Purpose: To summarize current knowledge regarding mechanisms of radiation-induced skin
injury and medical countermeasures available to reduce its severity. Advances in radiation …

Radiation damage to tumor vasculature initiates a program that promotes tumor recurrences

JM Brown - International Journal of Radiation Oncology* Biology …, 2020 - Elsevier
This review, mostly of preclinical data, summarizes the evidence that radiation at doses
relevant to radiation therapy initiates a pathway that promotes the reconstitution of the tumor …

Cellular characterization of ultrasound-stimulated microbubble radiation enhancement in a prostate cancer xenograft model

AA Al-Mahrouki, S Iradji, WT Tran… - Disease models & …, 2014 - journals.biologists.com
Tumor radiation resistance poses a major obstacle in achieving an optimal outcome in
radiation therapy. In the current study, we characterize a novel therapeutic approach that …

Impact of radiation therapy on healthy tissues

C Chargari, E Rassy, C Helissey, S Achkar… - International review of …, 2023 - Elsevier
Radiation therapy has a fundamental role in the management of cancers. However, despite
a constant improvement in radiotherapy techniques, the issue of radiation-induced side …

[HTML][HTML] Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

E Tabouret, A Tchoghandjian, E Denicolai, C Delfino… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Angiogenesis is one of the key features of glioblastoma (GBM). Our objective was to explore
the potential changes of angiogenic factors in GBM between initial diagnosis and recurrence …

Stromal cell–derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation

TJ Glass, TC Lund, X Patrinostro, J Tolar… - Blood, The Journal …, 2011 - ashpublications.org
In mammals, stromal cell–derived factor-1 (SDF-1) promotes hematopoietic cell mobilization
and migration. Although the zebrafish, Danio rerio, is an emerging model for studying …

Potential of serum microRNAs as biomarkers of radiation injury and tools for individualization of radiotherapy

B Tomasik, J Chałubińska-Fendler, D Chowdhury… - Translational …, 2018 - Elsevier
Due to tremendous technological advances, radiation oncologists are now capable of
personalized treatment plans and deliver the dose in a highly precise manner. However, a …