Targeting NADPH oxidases in vascular pharmacology

A Schramm, P Matusik, G Osmenda, TJ Guzik - Vascular pharmacology, 2012 - Elsevier
Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism,
which plays a key role in the pathogenesis of atherosclerosis, vascular inflammation and …

Glycation and antioxidants: hand in the glove of antiglycation and natural antioxidants

A Khanam, S Ahmad, A Husain… - Current Protein and …, 2020 - ingentaconnect.com
The non-enzymatic interaction of sugar and protein resulting in the formation of advanced
glycation end products responsible for cell signaling alterations ultimately leads to the …

Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect

N Ansari, F Khodagholi - Current neuropharmacology, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no
curative or preventive therapy. Histopathological hallmarks of AD include deposition of β …

Implication of caspase‐3 as a common therapeutic target for multineurodegenerative disorders and its inhibition using nonpeptidyl natural compounds

S Khan, K Ahmad, EMA Alshammari… - BioMed research …, 2015 - Wiley Online Library
Caspase‐3 has been identified as a key mediator of neuronal apoptosis. The present study
identifies caspase‐3 as a common player involved in the regulation of …

[HTML][HTML] Neuroprotective effects of allocryptopine-rich alkaloid extracts against oxidative stress-induced neuronal damage

SN Dolanbay, FG Kocanci, B Aslim - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Background Oxidative stress is a significant feature in the pathomechanism of
neurodegenerative diseases. Thus, the search for an effective and safe novel antioxidant …

Protective effects of wheat germ protein isolate hydrolysates (WGPIH) against hydrogen peroxide-induced oxidative stress in PC12 cells

KX Zhu, X Guo, XN Guo, W Peng, HM Zhou - Food research international, 2013 - Elsevier
The protective effects of the enzymatic hydrolysates of wheat germ protein isolate against
the cytotoxicity and apoptosis produced by exposure to H 2 O 2 in PC12 cells were …

Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury

M Porres-Martínez, E González-Burgos… - Food and Chemical …, 2015 - Elsevier
Salvia lavandulifolia Vahl., known as “Spanish sage”, has potential value in dementia for its
sedative, antioxidant, anti-inflammatory and anticholinesterase properties. This work aimed …

Synthetic and Natural Bioactive Molecules in Balancing the Crosstalk among Common Signaling Pathways in Alzheimer's Disease: Understanding the Neurotoxic …

AJ Shah, PA Mir, M Adnan, M Patel, M Maqbool… - ACS …, 2023 - ACS Publications
The structure and function of the brain greatly rely on different signaling pathways. The wide
variety of biological processes, including neurogenesis, axonal remodeling, the …

Small molecule natural products and Alzheimer's disease

X Wu, H Cai, L Pan, G Cui, F Qin… - Current topics in …, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive and deadly neurodegenerative disease that is
characterized by memory loss, cognitive impairment and dementia. Several hypotheses …

[HTML][HTML] Inactivation of PI3K/Akt pathway and upregulation of PTEN gene are involved in daucosterol, isolated from Salvia sahendica, induced apoptosis in human …

MA Esmaeili, MM Farimani - South African Journal of Botany, 2014 - Elsevier
Ethnopharmacological relevance Salvia sahendica has been traditionally used for
antibacterial, anti-fungal, and anti-cancer purposes and treatment of dyspepsia in many …