Background Seasonal malaria chemoprevention is used in 13 countries in the Sahel region
of Africa to prevent malaria in children younger than 5 years. Resistance of Plasmodium …

The development and rapid spread of chloroquine resistance (CQR) in Plasmodium
falciparum have triggered the identification of several genetic target (s) in the P. falciparum …

Drug-resistant micro-organisms became widespread in the 20th Century, often with
devastating consequences, in response to widespread use of natural and synthetic drugs …

Background The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium
falciparum malaria may be threatened by parasites with reduced responsiveness to …

Background Artemisinin-based combination therapy, currently considered the therapy of
choice for uncomplicated Plasmodium falciparum malaria in endemic countries, may be …

Abstract Background In Nigeria, despite the change in National malaria drug policy to
artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance …

Background The screening of lead compounds against in vitro parasite cultures is an
essential step in the development of novel anti-malarial drugs, but currently relies on …

As a result of widespread antimalarial drug resistance, all African countries with endemic
malaria have, in recent years, changed their malaria treatment policy. In Senegal, the health …

Abstract Background Resistance of Plasmodium falciparum to anti-malarial drugs has
hampered efforts to eradicate malaria. Recent reports of a decline in the prevalence of …

Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum
typically harbour multiple haploid clones. The apparent number of clones observed in any …