The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

The NLRP3 inflammasome in acute myocardial infarction

S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

Inflammation–cause or consequence of heart failure or both?

S Van Linthout, C Tschöpe - Current heart failure reports, 2017 - Springer
Abstract Purpose of Review With the intention to summarize the currently available evidence
on the pathophysiological relevance of inflammation in heart failure, this review addresses …

Chronic heart failure and inflammation: what do we really know?

SA Dick, S Epelman - Circulation research, 2016 - Am Heart Assoc
As a greater proportion of patients survive their initial cardiac insult, medical systems
worldwide are being faced with an ever-growing need to understand the mechanisms …

Role of innate and adaptive immune mechanisms in cardiac injury and repair

S Epelman, PP Liu, DL Mann - Nature Reviews Immunology, 2015 - nature.com
Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes

S Nirenjen, J Narayanan, T Tamilanban… - Frontiers in …, 2023 - frontiersin.org
Background Impaired wound healing is the most common and significant complication of
Diabetes. While most other complications of Diabetes have better treatment options, diabetic …

IL-17 and Th17 cells in atherosclerosis: subtle and contextual roles

S Taleb, A Tedgui, Z Mallat - Arteriosclerosis, thrombosis, and …, 2015 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory arterial disease driven by both innate and adaptive
immune responses to modified lipoproteins and components of the injured vascular wall …

Цитокины в патогенезе и лечении заболеваний человека

АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

An interleukin-23-interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis

AR Fatkhullina, IO Peshkova, A Dzutsev, T Aghayev… - Immunity, 2018 - cell.com
Although commensal flora is involved in the regulation of immunity, the interplay between
cytokine signaling and microbiota in atherosclerosis remains unknown. We found that …

The dynamic interplay between cardiac inflammation and fibrosis

TP Thomas, LA Grisanti - Frontiers in physiology, 2020 - frontiersin.org
Heart failure is a leading cause of death worldwide. While there are multiple etiologies
contributing to the development of heart failure, all cause result in impairments in cardiac …