The use of field-Effect-Transistor (FET) type biosensing arrangements has been highlighted
by researchers in the field of early biomarker detection and drug screening. Their non …

Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Diabetes is a chronic debilitating disease that results from insufficient production of insulin
from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently …

Tissue engineering can be used to restore, maintain, or enhance tissues and organs. The
potential impact of this field, however, is far broader—in the future, engineered tissues could …

Background Islet transplantation offers the potential to improve glycemic control in a
subgroup of patients with type 1 diabetes mellitus who are disabled by refractory …

Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …

Human embryonic stem cells (hESCs) are considered a potential alternative to cadaveric
islets as a source of transplantable cells for treating patients with diabetes. We previously …

Background Intraportal transplantation of pancreatic islets offers improved glycaemic control
and insulin independence in type 1 diabetes mellitus, but intraportal thrombosis remains a …

Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for
subjects who have labile diabetes or problems with hypoglycemic awareness. The risks of …